Efficiency

Table step one reveals the basic attributes of the ten,798 people that has done guidance about NHANES 1999–2004 study. Of them members, 2,123 (19.7%) had migrainepared so you’re able to non-headache, headache was more likely to getting younger, women, non-Latina Black, previous drinking, most recent puffing, possess all the way down knowledge top, all the way down prevalence out-of blood pressure, higher Body mass index, high carbs consumption, straight down calcium supplements and you will magnesium intake, and lower vitamin D enhance consumption. The average day-after-day consumption out-of calcium supplements and you will magnesium try rather down than simply their particular required fat loss allowances (RDAs), because found in the Dining table dos.

Table 3 shows a significant inverse association between dietary calcium and magnesium intake and migraine after adjusting for the possible confounders. The ORs (95% CI) for the association between dietary calcium intake and migraine were 0.85 (0.73–0.99) and 0.77 (0.63–0.93), comparing the Q2 (– mg/day) and Q5 (?1, mg/day) quintile of calcium with the lowest quintile (? mg/day), respectively. The ORs (95% CI) of Q2 (– mg/day), Q3 (– mg/day), Q4 (– mg/day), and Q5 (? mg/day) quintile of magnesium were 0.81 (0.69–0.95), 0.83 (0.70–0.98), 0.78 (0.65–0.94), and 0.69 (0.55–0.86) compared with Q1 (< mg/day).

Immediately following stratifying by the intercourse, brand new organization involving the highest while the lowest quintile out-of calcium supplements consumption and migraine stayed statistically tall in women and people. Getting diet magnesium, the fresh new Otherwise (95% CI) is actually 0.62 (0.47–0.83), comparing the best (? mg/d) and the reduced quintile (? mg/d) away from magnesium intake in females. Yet not, discover no mathematically tall organization ranging from fat loss magnesium intake and you can migraine into the men (Profile step one).

Contour step one. Data was indeed presented while the Otherwise (95% CI). Limitation contours suggest 95% CI. ORs have been adjusted to possess age, race/ethnicity, puffing, ingesting, marital, education height, Bmi, time intake, necessary protein intake, carbs intake, calcium enhance, magnesium enhance, nutritional D complement, blood pressure levels, diabetic issues, coronary arrest, coronary heart state, C reactive necessary protein, and you may total cholesterol levels.

We also examined the potential correlation and joint association between calcium and magnesium. We found that calcium and magnesium were highly correlated (r = 0.631; P < 0.001) (data are not shown). We divided participants into four groups based on the quintile intake of calcium and magnesium, after adjusting for potential confounders, joint analyses showed that the OR (95% CI) of migraine in the high-calcium and high-magnesium group was 0.77 (0.64–0.91) compared with the low-calcium and low-magnesium group. After stratifying by sex, the joint association of dietary calcium and magnesium remained significant in women. However, the joint association was not significant in men (Table 4).

In RCS, we observed a non-linear relationship between calcium and magnesium (continuously measured) and migraine. Significantly decreased ORs (<1.00) were observed when calcium intake ranged from 670 to 1,700 mg/day. The ORs decreased with increasing dietary magnesium levels and were significantly lower than 1.00 when dietary magnesium intake was higher than 243 mg/day (Figure 2).

Shape 2. Relationship ranging from dieting (A) calcium supplements and (B) magnesium consumption and nightmare for siti incontri alto profilo the RCS. The model is actually modified having decades, sex, race/ethnicity, smoking, taking, marital, studies height, Bmi, time consumption, necessary protein consumption, carb intake, calcium enhance, magnesium complement, supplement D complement, hypertension, all forms of diabetes, stroke, cardiovascular state, C activated healthy protein, and you may full cholesterol levels. Good line, OR; shade, 95% CI.

Dialogue

Within large get across-sectional investigation, i seen a keen inverse connection between dietary calcium and you can magnesium and you can migraine, independent away from tall confounders. Subgroup research revealed that calcium supplements and you will magnesium remained inversely with the migraine in women, correspondingly. For men, just higher fat loss calcium consumption try adversely related to migraine, however, there clearly was zero mathematically high relationship ranging from weightloss magnesium consumption and you will migraine. Furthermore, in the viewing the latest combined outcomes of calcium and you will magnesium, we discovered that high-calcium and you may large-magnesium consumption is inversely of the migraine in women, consistent with our study of the fresh new separate effects of calcium supplements and you will magnesium.